Between noise and function: Toward a taxonomy of the non-canonical translatome

Zachary Ardern; Md Hassan Uz-Zaman

doi:10.1016/j.cels.2023.04.004

Between noise and function: Toward a taxonomy of the non-canonical translatome

Cell Syst. 2023 May 17;14(5):343-345. doi: 10.1016/j.cels.2023.04.004.

Authors

Zachary Ardern¹, Md Hassan Uz-Zaman²

Affiliations

¹ Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK. Electronic address: zachary.ardern@sanger.ac.uk.
² Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. Electronic address: h.uzzaman@utexas.edu.

PMID: 37201506
DOI: 10.1016/j.cels.2023.04.004

Abstract

Eukaryotic genomes are pervasively translated, but the properties of translated sequences outside of canonical genes are poorly understood. A new study in Cell Systems reveals a large translatome that is not under significant evolutionary constraint but is still an active part of diverse cellular systems.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Biological Evolution*
Genome*

Grants and funding

220540/Z/20/A/WT_/Wellcome Trust/United Kingdom