Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi; Vanessa Klapp; Silvia C Formenti; Sandra Demaria; Lorenzo Galluzzi

doi:10.1042/EBC20220248

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Essays Biochem. 2023 Sep 28;67(6):979-989. doi: 10.1042/EBC20220248.

Authors

Claudia Galassi¹, Vanessa Klapp^{2

3}, Silvia C Formenti^{1

4

5}, Sandra Demaria¹, Lorenzo Galluzzi^{1

5

6}

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, U.S.A.
² Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
³ Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
⁴ Department of Medicine, Weill Cornell Medical College, New York, NY, U.S.A.
⁵ Sandra and Edward Meyer Cancer Center, New York, NY, U.S.A.
⁶ Caryl and Israel Englander Institute for Precision Medicine, New York, NY, U.S.A.

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Keywords: CGAS; ICD; TGFβ; TREG cells; mtDNA; type I IFN.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antineoplastic Agents*
Humans
Neoplasms* / pathology
Neoplasms* / radiotherapy
Tumor Microenvironment

Substances

Antineoplastic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding