Objective: To compare the clinical efficacy of thumb-tack needle and sodium hyaluronate eye drops for dry eye.
Methods: A total of 60 patients with dry eye were randomly divided into a thumb-tack needle group and a western medication group, 30 cases in each group. Based on Biaoben Genjie theory, thumb-tack needle was applied at Zhiyin (BL 67), Lidui (ST 45), Fuyang (BL 59), Yanglao (SI 6), Jingming (BL 1) and Cuanzhu (BL 2) in the thumb-tack needle group, 2 times a week. In the western medication group, 0.1% sodium hyaluronate eye drops were applied, 3 times a day. Both groups were treated for 4 weeks. Before and after treatment, TCM symptom score, tear film break-up time (BUT), SchirmerⅠtest (SⅠT), corneal fluorescein sodium staining (FL) score and 36-item short form health survey (SF-36) score were observed, and the clinical efficacy was evaluated in the two groups.
Results: After treatment, the total scores and each item score of TCM symptom in the two groups were decreased compared with before treatment (P<0.05); except for score of visual fatigue and photophobia, the total score and each item score of TCM symptom in the thumb-tack needle group were lower than the western medication group (P<0.05). After treatment, the BUT, SⅠT and SF-36 scores were increased and the FL scores were decreased in the two groups (P<0.05); the BUT, SⅠT and SF-36 score were higher than the western medication group (P<0.05), and the FL score was lower than the western medication group (P<0.05) in the thumb-tack needle group. The total effective rate in the thumb-tack needle group was 93.3% (28/30), which was higher than 80.0% (24/30) in the western medication group (P<0.05).
Conclusion: Thumb-tack needle based on Biaoben Genjie theory could effectively relieve clinical symptoms of dry eye patients, prolong tear film break-up time, increase tear secretion, improve tear film function and quality of life, and its curative effect is better than sodium hyaluronate eye drops.
目的：比较揿针埋针与玻璃酸钠滴眼液治疗干眼的临床疗效。方法：将60例干眼患者随机分为揿针组和西药组，各30例。揿针组基于“标本根结”理论选取至阴、厉兑、跗阳、养老、睛明、攒竹行揿针埋针治疗，每周2次；西药组采用0.1%玻璃酸钠滴眼液治疗，每日3次，均治疗4周。分别于治疗前后观察两组患者中医症状评分、泪膜破裂时间（BUT）、泪液分泌试验（SⅠT）、角膜荧光素钠染色（FL）评分、健康调查简表（SF-36）评分，并评定两组临床疗效。结果：治疗后，两组患者各项中医症状评分及总分均较治疗前降低（P<0.05）；除视物疲劳、畏光症状评分外，揿针组患者各项中医症状评分及总分均低于西药组（P<0.05）。治疗后，两组患者BUT延长、SⅠT增加、FL评分降低、SF-36评分增加（P<0.05）；揿针组患者BUT、SⅠT、SF-36评分高于西药组（P<0.05），FL评分低于西药组（P<0.05）。揿针组总有效率为93.3%（28/30），高于西药组的80.0%（24/30，P<0.05）。结论：基于“标本根结”理论的揿针埋针治疗可有效缓解干眼患者临床症状，延长泪膜破裂时间，增加泪液分泌量，提高泪膜功能及患者生活质量，疗效优于玻璃酸钠滴眼液治疗。.
Keywords: Biaoben Genjie; dry eye; quality of life; randomized controlled trial (RCT); sodium hyaluronate eye drops; tear film function; thumb-tack needle.