Proliferative Glomerulonephritis with Monoclonal Immunoglobulins in a Child with Recurrence in the Allograft

Indian J Nephrol. 2023 Jan-Feb;33(1):65-69. doi: 10.4103/ijn.ijn_380_21. Epub 2022 Oct 2.

Abstract

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is among the spectrum of monoclonal protein-associated renal diseases, with only about 15 case reports in children. We report a 7-year-old boy with biopsy-proven crescentic PGNMID who progressed to end-stage renal disease within a few months of presentation. He then received a renal transplant with his grandmother as a donor. Proteinuria was detected at 27 months post-transplant and an allograft biopsy revealed a recurrent disease.

Keywords: Monoclonal gammopathy; PGNMID; recurrence.

Publication types

  • Case Reports