Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance

Mengsi Zhang; Lu Wang; Hao Jin; Nan Zhao; Yi Liu; Shijie Lan; Shuwei Liu; Hao Zhang

doi:10.1016/j.jconrel.2023.05.020

Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance

J Control Release. 2023 Jun:358:612-625. doi: 10.1016/j.jconrel.2023.05.020. Epub 2023 May 19.

Authors

Mengsi Zhang¹, Lu Wang², Hao Jin¹, Nan Zhao³, Yi Liu⁴, Shijie Lan⁵, Shuwei Liu⁶, Hao Zhang⁷

Affiliations

¹ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
² Department of Pediatric Dentistry, Hospital of Stomatology, Jilin University, Changchun 130021, PR China.
³ Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130031, PR China.
⁴ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China; Joint Laboratory of Optical Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, PR China.
⁵ Cancer Center, The First Hospital of Jilin University, Changchun 130021, PR China. Electronic address: lanshijie@jlu.edu.cn.
⁶ Joint Laboratory of Optical Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, PR China. Electronic address: liushuwei@jlu.edu.cn.
⁷ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China; Joint Laboratory of Optical Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, PR China; Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address: hao_zhang@jlu.edu.cn.

PMID: 37196899
DOI: 10.1016/j.jconrel.2023.05.020

Abstract

Metal-phenolic networks (MPNs) have been conventionally formed by the coordination of metal ions and polyphenols, which can responsively release metal ions and polyphenols under the trigger of tumor microenvironment (TME), showing high potential in the field of antitumor. However, MPNs are mainly limited to multi-valency polyphenols, and the unavailability of single valency polyphenols greatly hinders their applications even though they have excellent antitumor activity. Herein, we demonstrate a FeOOH assisted preparation method for MPNs antitumor reagent by introducing the complexes of Fe³⁺, H₂O and polyphenol (Fe(H₂O)_x-polyphenol_y) in the preparation process, which overcomes the shortage of single valency polyphenols. Taking apigenin (Ap) as an example, Fe(H₂O)_x-Ap_y complexes are foremost formed, in which the Fe(H₂O)_x is capable of hydrolyzing to generate FeOOH, thus producing Fe³⁺-Ap networks-coated FeOOH nanoparticles (FeOOH@Fe-Ap NPs). Under the stimulation of the TME, FeOOH@Fe-Ap NPs could release Fe²⁺ and Ap, realizing ferroptosis and apoptosis for tumor combination therapy. In addition, FeOOH can shorten transverse relaxation time, acting as a T₂-weighted magnetic resonance imaging contrast agent. The current efforts provide an alternative strategy for constructing MPNs by exploiting single valency polyphenols, which strengthens the potential of MPNs in antitumor applications.

Keywords: Apigenin; FeOOH; Ferroptosis; Metal-phenolic networks; Single valency polyphenol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media
Indicators and Reagents
Magnetic Resonance Imaging
Nanoparticles*
Polyphenols*

Substances

Polyphenols
Indicators and Reagents
Contrast Media