Air pollution, EGFR mutation, and cancer initiation

Si-Chong Han; Gui-Zhen Wang; Guang-Biao Zhou

doi:10.1016/j.xcrm.2023.101046

Air pollution, EGFR mutation, and cancer initiation

Cell Rep Med. 2023 May 16;4(5):101046. doi: 10.1016/j.xcrm.2023.101046.

Authors

Si-Chong Han¹, Gui-Zhen Wang¹, Guang-Biao Zhou²

Affiliations

¹ State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
² State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: gbzhou@cicams.ac.cn.

Abstract

Swanton et al.¹ find that PM_2.5 exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM_2.5 increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

Publication types

Comment

MeSH terms

Air Pollution* / adverse effects
ErbB Receptors / genetics
Humans
Lung Neoplasms* / epidemiology
Lung Neoplasms* / genetics
Mutation
Particulate Matter / adverse effects

Substances

Particulate Matter
ErbB Receptors
EGFR protein, human