Hebbian and homeostatic synaptic plasticity of AMPA receptors in epileptogenesis

Giulia Curia

doi:10.1016/j.xcrm.2023.101047

Hebbian and homeostatic synaptic plasticity of AMPA receptors in epileptogenesis

Cell Rep Med. 2023 May 16;4(5):101047. doi: 10.1016/j.xcrm.2023.101047.

Author

Giulia Curia¹

Affiliation

¹ Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: giulia.curia@unimore.it.

Abstract

AMPA receptors' synaptic plasticity is involved in epileptogenesis. In this issue, Eiro et al.¹ demonstrate that Hebbian plasticity is responsible for increased AMPAR in focal seizures, while homeostatic plasticity induces the reduction of AMPAR in generalized onset seizures.

Publication types

Comment

MeSH terms

Homeostasis
Neuronal Plasticity
Receptors, AMPA*
Synapses*

Substances

Receptors, AMPA