A dual-function probe with aggregation-induced emission feature for Cu2+ detection and chemodynamic therapy

Juan Fu; Xin Hu; Teng Guo; Weifeng Zhu; Jianwen Tian; Meiying Liu; Xiaoyong Zhang; Yen Wei

doi:10.1039/d2cc06350f

A dual-function probe with aggregation-induced emission feature for Cu²⁺ detection and chemodynamic therapy

Chem Commun (Camb). 2023 May 30;59(44):6738-6741. doi: 10.1039/d2cc06350f.

Authors

Juan Fu¹, Xin Hu¹, Teng Guo¹, Weifeng Zhu², Jianwen Tian¹, Meiying Liu^{1

2}, Xiaoyong Zhang¹, Yen Wei^{3

4}

Affiliations

¹ Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China. lmy5305@iccas.ac.cn.
² Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
³ Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, P. R. China. weiyen@tsinghua.edu.cn.
⁴ Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology, Chung-Yuan Christian University, Chung-Li 32023, Taiwan.

PMID: 37194318
DOI: 10.1039/d2cc06350f

Abstract

Herein, a fluorescent probe (named TPACP) with aggregation-induced emission (AIE) feature was developed and utilized for the selective detection of Cu²⁺ with high sensitivity and fast-response. The resultant TPACP@Cu²⁺ complexes from coordination of TPACP with Cu²⁺ can also be potentially applied for chemodynamic and photodynamic therapy.

MeSH terms

Coordination Complexes / chemistry
Coordination Complexes / pharmacology
Copper / chemistry
Fluorescent Dyes* / pharmacology
Photochemotherapy*

Substances

Fluorescent Dyes
Coordination Complexes
Copper