Albumin binding improves nanobody pharmacokinetics for dual-modality PET/NIRF imaging of CEACAM5 in colorectal cancer models

Affiliations

• ¹ Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ² Hubei Key Laboratory of Molecular Imaging, Wuhan, China.
• ³ Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.
• ⁴ Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
• ⁵ Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xiaoli_lan@hust.edu.cn.
• ⁶ Hubei Key Laboratory of Molecular Imaging, Wuhan, China. xiaoli_lan@hust.edu.cn.
• ⁷ Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA. wcai@uwhealth.org.