Ultra-selective 1D clean in-phase correlation spectroscopy

Chem Commun (Camb). 2023 May 30;59(44):6734-6737. doi: 10.1039/d3cc01333b.

Abstract

Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.