The roles of ERIANIN in tumor and innate immunity and its' perspectives in immunotherapy

Zhen Yang; Ruxue Liu; Minghan Qiu; Hanwei Mei; Jie Hao; Teng Song; Ke Zhao; Dandan Zou; Huaqing Wang; Ming Gao

doi:10.3389/fimmu.2023.1170754

The roles of ERIANIN in tumor and innate immunity and its' perspectives in immunotherapy

Front Immunol. 2023 Apr 28:14:1170754. doi: 10.3389/fimmu.2023.1170754. eCollection 2023.

Authors

Zhen Yang^{1

2}, Ruxue Liu³, Minghan Qiu^{1

2}, Hanwei Mei³, Jie Hao⁴, Teng Song^{1

2}, Ke Zhao^{1

2}, Dandan Zou^{1

2}, Huaqing Wang^{1

2

3}, Ming Gao⁴

Affiliations

¹ Department of Oncology, Tianjin Union Medical Center of Nankai University, Tianjin, China.
² The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China.
³ College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
⁴ Department of Thyroid and Breast Surgery, Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center, Tianjin, China.

Abstract

Traditional Chinese medicine has been used in China for thousands of years. In 2022, the 14th Five-Year Plan for the Development of Traditional Chinese Medicine was released, aiming to enhance traditional Chinese medicine health services and improve policies and systems for high-quality traditional Chinese medicinal development by 2025. ERIANIN, the main component of the traditional Chinese medicine Dendrobium, plays an important role in anti-inflammatory, antiviral, antitumor, antiangiogenic, and other pharmacological effects. ERIANIN has broad-spectrum antitumor effects, and its tumor-suppressive effects have been confirmed in the study of various diseases, such as precancerous lesions of the stomach, gastric cancer, liver cancer, lung cancer, prostate cancer, bladder cancer, breast cancer, cervical cancer, osteosarcoma, colorectal cancer, leukaemia, nasopharyngeal cancer and melanoma through the multiple signaling pathways. Thus, the aim of this review was to systematically summarise the research on ERIANIN with the aim of serving as a reference for future research on this compound and briefly discuss some future perspectives development of ERIANIN in combined immunotherapy.

Keywords: ERIANIN; cancer; immunotherapy; innate immunity; signaling pathways; traditional Chinese medicine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bone Neoplasms*
Humans
Immunity, Innate
Immunotherapy
Male
Nasopharyngeal Neoplasms*

Substances

Erianin

Grants and funding

This work was partially supported by Tianjin Key Medical Discipline (Specialty) Construction Project (Grant No. TJYXZDXK-053B, TJYXZDXK-058B); National Natural Science Foundation of China (Grant No.82070206).