Intersection of nanomaterials and organoids technology in biomedicine

Chen Shen; Zi-Jian Zhang; Xiao-Xue Li; Yun-Peng Huang; Yong-Xiang Wang; Hui Zhou; Li Xiong; Yu Wen; Heng Zou; Zhong-Tao Liu

doi:10.3389/fimmu.2023.1172262

Intersection of nanomaterials and organoids technology in biomedicine

Front Immunol. 2023 Apr 28:14:1172262. doi: 10.3389/fimmu.2023.1172262. eCollection 2023.

Authors

Affiliations

¹ Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types that can form functional "micro-organs" and can be used to simulate the occurrence process and physiological pathological state of organ tissues more effectively. Nanomaterials (NMs) are becoming indispensable in the development of novel organoids. Understanding the application of nanomaterials in organoid construction can, therefore, provide researchers with ideas for the development of novel organoids. Here, we discuss the application status of NMs in various organoid culture systems and the research direction of NMs combined with organoids in the biomedical field.

Keywords: 3D culture; biomedicine; nanomaterials; nanoparticles; organoids.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Culture Techniques / methods
Nanostructures*
Organoids*
Stem Cells / metabolism
Technology

Grants and funding

This research was supported by Fundamental Research Funds for the National Natural Science Foundation of China, No. 81970569, Fundamental Research Funds for the Central Universities of Central South University, No. 2021zzts0367 and Hunan Provincial Innovation Foundation for Postgraduate, No. CX20210369.