MnO2 Coated Mesoporous PdPt Nanoprobes for Scavenging Reactive Oxygen Species and Solving Acetaminophen-Induced Liver Injury

Yi Lu; Xinni Pan; Cheng Cao; Shanshan Fan; Haisong Tan; Shengsheng Cui; Yanlei Liu; Daxiang Cui

doi:10.1002/adhm.202300163

MnO₂ Coated Mesoporous PdPt Nanoprobes for Scavenging Reactive Oxygen Species and Solving Acetaminophen-Induced Liver Injury

Adv Healthc Mater. 2023 Sep;12(22):e2300163. doi: 10.1002/adhm.202300163. Epub 2023 May 25.

Authors

Yi Lu¹, Xinni Pan², Cheng Cao¹, Shanshan Fan², Haisong Tan³, Shengsheng Cui¹, Yanlei Liu¹, Daxiang Cui¹

Affiliations

¹ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
² Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200235, P. R. China.
³ Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.

PMID: 37184887
DOI: 10.1002/adhm.202300163

Abstract

As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO₂ nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase-like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)-scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs' therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.

Keywords: PdPt@MnO2 nanoprobes; acute liver injury; multienzyme-like activity; nanozymes; reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen* / pharmacology
Chemical and Drug Induced Liver Injury, Chronic* / pathology
Humans
Liver
Manganese Compounds
Oxides
Reactive Oxygen Species

Substances

Acetaminophen
Reactive Oxygen Species
Manganese Compounds
Oxides