Nurse-Supervised Exercise for People with Stage IV Cancer: The EFICANCER Randomized Clinical Trial

Nere Mendizabal-Gallastegui; Maria Soledad Arietaleanizbeaskoa; Pedro Maria Latorre; Arturo García-Álvarez; Aintzane Sancho; Eluska Iruarrizaga; Guillermo López-Vivanco; Gonzalo Grandes

doi:10.1016/j.soncn.2023.151448

Nurse-Supervised Exercise for People with Stage IV Cancer: The EFICANCER Randomized Clinical Trial

Semin Oncol Nurs. 2023 Aug;39(4):151448. doi: 10.1016/j.soncn.2023.151448. Epub 2023 May 13.

Authors

Nere Mendizabal-Gallastegui¹, Maria Soledad Arietaleanizbeaskoa², Pedro Maria Latorre³, Arturo García-Álvarez⁴, Aintzane Sancho⁵, Eluska Iruarrizaga⁵, Guillermo López-Vivanco⁶, Gonzalo Grandes⁷

Affiliations

¹ Research Nurse, Primary Care Group on Health, Prevention and Chronic Diseases, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, España. Electronic address: nere.mendizabalgallastegui@osakidetza.eus.
² Research Nurse, Primary Care Group on Health, Prevention and Chronic Diseases, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, España.
³ Medical Epidemiologist, Primary Care Group on Health, Prevention and Chronic Diseases, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, España.
⁴ Statistician, Primary Care Group on Health, Prevention and Chronic Diseases, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, España.
⁵ Oncologist, Biobizkaia Health Research Institute Medical Oncology Group, Barakaldo, Bizkaia, España.
⁶ Head of the Oncology Department at Cruces University Hospital, Biobizkaia Health Research Institute Medical Oncology Group, Barakaldo, Bizkaia, España.
⁷ Head of the Primary Care Research Unit of Bizkaia, Primary Care Group on Health, Prevention and Chronic Diseases, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, España.

PMID: 37183104
DOI: 10.1016/j.soncn.2023.151448

Abstract

Objectives: To assess the effectiveness of the EFICANCER individualized and supervised exercise program for people with gastrointestinal, breast, or non-small cell lung stage IV cancer, in terms of quality of life and functional capacity.

Data sources: Randomized controlled clinical trial with two parallel groups: EFICANCER (n = 47) and control (n = 43). Both groups received standard oncological care. In addition, the EFICANCER group participated in a nurse-supervised exercise program. Primary outcome was cancer-specific (EORTC QLQ-C30 questionnaire) and general quality of life (SF-36) at baseline and after 2, 6, and 12 months. Secondary outcomes were functional capacity (6-minute walking test), strength, and fatigue. The evolution in both groups was compared over 12 months using mixed-effect longitudinal models; 74.47% of patients completed at least one session of the program. At 12 months, EFICANCER group had better scores in cancer-related quality of life, with a difference between groups of 15.7 points (95% confidence interval 4.4 to 25.9) and in functional capacity, with a difference of 4.5 points (95% confidence interval -0.5 to 9.5). No significant differences in any other secondary variables were observed.

Conclusion: The EFICANCER primary care nurse supervised exercise program is safe and feasible and improves cancer patient's outcomes.

Implications for nursing practice: Providing the best care and trying to improve the quality of life of cancer patients are essential parts of nursing practice. Eficancer adds a new dimension to nursing practice by providing greater attention and care to patients during treatment through the supervision of physical exercise, thereby contributing to improve the quality of life of this population.

Trial registration: ClinicalTrials.gov NCT01786122.

Keywords: Advanced stage cancer; Functional capacity; Nurses; Quality of life; Supervised physical exercise.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Non-Small-Cell Lung*
Exercise
Exercise Therapy / methods
Humans
Lung Neoplasms*
Quality of Life

Associated data

ClinicalTrials.gov/NCT01786122