Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent

Lingyu Zhao; Xiaowei Ding; Imran Mahmood Khan; Lin Yue; Yin Zhang; Zhouping Wang

doi:10.1016/j.carbpol.2023.120852

Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent

Carbohydr Polym. 2023 Aug 1:313:120852. doi: 10.1016/j.carbpol.2023.120852. Epub 2023 Mar 25.

Authors

Lingyu Zhao¹, Xiaowei Ding¹, Imran Mahmood Khan¹, Lin Yue², Yin Zhang³, Zhouping Wang⁴

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China. Electronic address: yuelin@jiangnan.edu.cn.
³ Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, PR China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, PR China. Electronic address: wangzp@jiangnan.edu.cn.

PMID: 37182952
DOI: 10.1016/j.carbpol.2023.120852

Abstract

Curcumin (Cur) is a natural pigment with excellent biological activity. The poor stability and insolubility of Cur in water severely limit its application. Therefore, to overcome these dilemmas which are big hindrances in their application, a novel derivative (COCS-Cur) was prepared by the esterification reaction of carboxylated chitosan (COCS) and Cur. The structure and properties of conjugate were determined through a series of characterizations. The derivatives had excellent solubility as well as stability. In addition, antioxidant and photodynamic antibacterial experiments proved that COCS-Cur had the excellent free radical scavenging ability and photodynamic antibacterial activity. The derivatives presented a better antibacterial effect on Staphylococcus aureus (S. aureus) than Escherichia coli (E. coli). Noteworthy, the COCS-Cur derivatives showed no obvious toxicity which makes them a stronger contender and potential antimicrobial agent or functional nutrient for application in the food industry.

Keywords: Antioxidant activity; Chitosan; Curcumin; Photodynamic sterilization; Stability; Water solubility.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Chitosan* / chemistry
Chitosan* / pharmacology
Curcumin* / chemistry
Escherichia coli
Staphylococcus aureus

Substances

Curcumin
Chitosan
Anti-Bacterial Agents