Role of Autophagy Pathway in Parkinson's Disease and Related Genetic Neurological Disorders

Christos Themistokleous; Enrico Bagnoli; Ramaa Parulekar; Miratul M K Muqit

doi:10.1016/j.jmb.2023.168144

Role of Autophagy Pathway in Parkinson's Disease and Related Genetic Neurological Disorders

J Mol Biol. 2023 Jun 15;435(12):168144. doi: 10.1016/j.jmb.2023.168144. Epub 2023 May 13.

Authors

Christos Themistokleous¹, Enrico Bagnoli², Ramaa Parulekar³, Miratul M K Muqit⁴

Affiliations

¹ MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK of Dundee, Dundee DD1 5EH, UK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: https://twitter.com/ChrisTmsk.
² MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK of Dundee, Dundee DD1 5EH, UK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: https://twitter.com/EnricoBagnoli2.
³ MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK of Dundee, Dundee DD1 5EH, UK.
⁴ MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK of Dundee, Dundee DD1 5EH, UK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: m.muqit@dundee.ac.uk.

PMID: 37182812
DOI: 10.1016/j.jmb.2023.168144

Abstract

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in the elimination of damaged mitochondria by autophagy (mitophagy) has provided unprecedented understanding of the mechanistic pathways underlying Parkinson's disease (PD). We provide a comprehensive overview of the general importance of autophagy in Parkinson's disease and related disorders of the central nervous system. This reveals a critical link between autophagy and neurodegenerative and neurodevelopmental disorders and suggests that strategies to modulate mitophagy may have greater relevance in the CNS beyond PD.

Keywords: PINK1; Parkin; Parkinson’s disease; autophagy; mitophagy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autophagy* / genetics
Central Nervous System
Humans
Mitophagy* / genetics
Parkinson Disease* / genetics
Parkinson Disease* / metabolism
Protein Kinases / genetics
Protein Kinases / metabolism
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism

Substances

Protein Kinases
Ubiquitin-Protein Ligases

Grants and funding

210753/Z/18/Z/WT_/Wellcome Trust/United Kingdom