Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment

Hao Hu; Junxu Yang; Yanping Zhong; Jiawei Wang; Jinhong Cai; Cuijuan Luo; Zhiqiang Jin; Ming Gao; Maolin He; Li Zheng

doi:10.1016/j.isci.2023.106605

Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment

iScience. 2023 Apr 18;26(5):106605. doi: 10.1016/j.isci.2023.106605. eCollection 2023 May 19.

Authors

Hao Hu^{1

2}, Junxu Yang^{1

3}, Yanping Zhong⁴, Jiawei Wang^{1

5}, Jinhong Cai^{1

5}, Cuijuan Luo⁴, Zhiqiang Jin^{1

5

3}, Ming Gao^{1

5

6}, Maolin He^{1

2}, Li Zheng^{1

5

6}

Affiliations

¹ Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
² Department of Spine Osteopathia, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
³ Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
⁴ Life Sciences Institute of Guangxi Medical University, Nanning 530021, China.
⁵ Collaborative Innovation Center of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
⁶ Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Abstract

Excessive reactive oxygen species (ROS) in joints could lead to gradual degeneration of the extracellular matrix (ECM) and apoptosis of chondrocytes, contributing to the occurrence and development of osteoarthritis (OA). Mimicking natural enzymes, polydopamine (PDA)-based nanozymes showed great potential in treating various inflammatory diseases. In this work, PDA loaded with ultra-small palladium (PDA-Pd) nanoparticles (NPs) was employed to scavenge ROS for OA therapy. As a result, PDA-Pd effectively declined the intracellular ROS levels and exhibited efficient antioxidative and anti-inflammatory capacity with good biocompatibility in IL-1β stimulated chondrocytes. Significantly, assisted with near-infrared (NIR) irradiation, its therapeutic effect was further enhanced. Further, NIR-stimulated PDA-Pd suppressed the progression of OA after intra-articular injection in the OA rat model. With favorable biocompatibility, PDA-Pd exhibits efficient antioxidative and anti-inflammatory capacity, leading to the alleviation of OA in rats. Our findings may provide new insights into the treatment of various ROS-induced inflammatory diseases.

Keywords: Biomedical materials; Health technology.