Unexpected Increase in Invasive Group A Streptococcal Infections in Children After Respiratory Viruses Outbreak in France: A 15-Year Time-Series Analysis

Yannis Lassoued; Zein Assad; Naim Ouldali; Marion Caseris; Patricia Mariani; Andre Birgy; Stephane Bonacorsi; Philippe Bidet; Albert Faye

doi:10.1093/ofid/ofad188

Unexpected Increase in Invasive Group A Streptococcal Infections in Children After Respiratory Viruses Outbreak in France: A 15-Year Time-Series Analysis

Open Forum Infect Dis. 2023 Apr 6;10(5):ofad188. doi: 10.1093/ofid/ofad188. eCollection 2023 May.

Authors

Yannis Lassoued¹, Zein Assad¹, Naim Ouldali^{1

2

3

4}, Marion Caseris¹, Patricia Mariani^{4

5}, Andre Birgy^{2

4

5}, Stephane Bonacorsi^{2

4

5}, Philippe Bidet^{2

4

5}, Albert Faye^{1

4

6}

Affiliations

¹ Department of General Pediatrics, Pediatric Infectious Disease and Internal Medicine, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
² Infection, Antimicrobials, Modelling, Evolution, INSERM UMR 1137, Paris Cité University, Paris, France.
³ ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, St Maur-des-Fossés, France.
⁴ Infection, Antimicrobials, Modelling, Evolution (IAME), Paris Cité University, UFR de Médecine Paris Nord, 75010 Paris, France.
⁵ Department of Microbiology, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁶ ECEVE, INSERM UMR 1123, Paris Cité University, Paris, France.

Abstract

In a 15-year pediatric time-series analysis, we showed a rise of invasive Group A streptococcal (iGAS) infections since October 2022, mainly involving pleural empyema, simultaneously to a respiratory virus outbreak. Physicians should be aware of this increased risk of pediatric iGAS infections, especially in settings with intense respiratory viruses' circulation.

Keywords: Streptococcus pyogenes; invasive Group A streptococcal infections; pediatrics; respiratory virus.