"Cross-talk" between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Su Liu; Guoqing Li; Huihui Xu; Qichang Wang; Yihao Wei; Qi Yang; Ao Xiong; Fei Yu; Jian Weng; Hui Zeng

doi:10.3389/fimmu.2023.1150572

"Cross-talk" between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Front Immunol. 2023 Apr 25:14:1150572. doi: 10.3389/fimmu.2023.1150572. eCollection 2023.

Authors

Su Liu^{1

2}, Guoqing Li^{1

2}, Huihui Xu^{1

2}, Qichang Wang^{1

2}, Yihao Wei^{1

2}, Qi Yang³, Ao Xiong^{1

2}, Fei Yu^{1

2}, Jian Weng^{1

2}, Hui Zeng^{1

2}

Affiliations

¹ Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, China.
² National and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, China.
³ Department of Ultrasonography, Peking University Shenzhen Hospital, Shenzhen, China.

Abstract

Objectives: The aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.

Methods: A systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords "Gut Microbiome" and "Osteoarthritis" was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.

Results: There were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.

Conclusion: There is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.

Keywords: cartilage; gut microbiome; immune response; inflammation; osteoarthritis.

Publication types

Systematic Review

MeSH terms

Animals
Dysbiosis
Gastrointestinal Microbiome*
Humans
Inflammation
Osteoarthritis*
Prospective Studies

Grants and funding

This research was continuously funded by National Natural Science Foundation of China (No. 82172432; No. 82102568 and No. 82001319); National and Local Joint Engineering Research Center of Orthopaedic Biomaterials (No. XMHT20190204007); Shenzhen High-level Hospital Construction Fund, Shenzhen Key Medical Discipline Construction Fund (No. SZXK023); Shenzhen “San-Ming” Project of Medicine (No. SZSM201612092); Research and Development Projects of Shenzhen (No. KCXFZ20201221173411031;No. JCYJ20210324110214040; No. JCYJ20220531094214032; No. JCYJ20190809152409606); Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515012586; No. 2021A1515220054; No. 2022B1515120046; No. 2022A1515220038; No. 2022A1515220111); the Scientific Research Foundation of PEKING UNIVERSITY SHENZHEN HOSPITAL (No. KYQD2021099).