Does tranexamic acid have its place in the prevention of postpartum hemorrhage?

Lionel Bouvet; Thibaut Rackelboom; Anne Sophie Bouthors; Estelle Morau; CARO working group

doi:10.1016/j.accpm.2023.101241

Does tranexamic acid have its place in the prevention of postpartum hemorrhage?

Anaesth Crit Care Pain Med. 2023 Aug;42(4):101241. doi: 10.1016/j.accpm.2023.101241. Epub 2023 May 11.

Authors

Lionel Bouvet¹, Thibaut Rackelboom², Anne Sophie Bouthors³, Estelle Morau⁴; CARO working group

Collaborators

CARO working group:
Anne Sophie Baptiste⁵, Dan Benhamou⁶, Marie Pierre Bonnet⁷, Martine Bonnin⁸, Anne Sophie Bouthors⁹, Lionel Bouvet¹, Dominique Chassard¹, Pierre Yves Dewandre¹⁰, Catherine Fisher¹¹, Max Gonzalez¹², Benjamin Julliac¹³, Hawa Keita¹⁴, Agnès Le Gouez¹⁵, Frédéric J Mercier¹⁶, Estelle Morau¹⁷, Thibaut Rackelboom¹⁸, Florence Vial¹⁹

Affiliations

¹ Department of Anesthesiology and Critical Care, Groupement Hospitalier Est, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.
² Department of Anesthesiology Intensive Care and Perioperative Medicine, CHU de Bordeaux, Bordeaux, France.
³ Department of Anesthesiology and Critical Care, Jeanne de Flandre Women's Hospital, Academic Hospital, 59037 Lille, France; Univ. Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
⁴ Department of Anesthesia, Intensive Care and Perioperative Medicine, CHU Nîmes, Nîmes, France. Electronic address: estelle.morau@chu-nimes.fr.
⁵ Department of Anesthesia, Hôpital de Roubaix, France.
⁶ Department of Anesthesia, Intensive Care and Perioperative Medicine AP-HP, Université Paris Saclay, Hôpital Bicêtre, Paris, France.
⁷ Department of Anesthesiology and Critical Care, Hôpital Armand Trousseau, DMU DREAM, Assistance Publique des Hôpitaux de Paris, France; Université de Paris, Centre for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPE, INSERM, INRA, Paris, France.
⁸ Department of Anesthesia and Critical Care Medicine, Pôle Anesthesie-Reanimation-Estaing, Clermont-Ferrand, France.
⁹ Department of Anesthesiology and Critical Care, Jeanne de Flandre Women's Hospital, Academic hospital, 59037 Lille France; Univ. Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
¹⁰ Department of Anesthesiology and Critical Care Liège, Belgique.
¹¹ Department of Anesthesiology and Critical Care, Hôpital Cochin-Port Royal, AP-HP, Paris, France.
¹² Department of Anesthesiology and Critical Care, Jeanne de Flandre Women's Hospital.
¹³ Department of Anesthesiology and Critical Care, Maison de Santé protestante de Bagatelle, Bordeaux France.
¹⁴ Department of Anesthesiology and Critical Care, Hôpital Necker-Enfants-Malades, AP-HP; Centre - Université de Paris, France, Unité de Recherche EA 7323 Pharmacologie et Evaluation des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Université de Paris, France.
¹⁵ Department of Anesthesia and Critical Care Medicine, Hôpital Antoine Béclère, AP-HP, Clamart, France.
¹⁶ Department of Anesthesia and Critical Care Medicine, Hôpital Antoine Béclère, AP-HP. Université Paris-Saclay, Clamart, France.
¹⁷ Department of Anaesthesia Intensive Care and Perioperative Medicine, CHU Nimes, Nîmes, France.
¹⁸ Department of Anaesthesia Intensive Care and Perioperative Medicine, CHU de Bordeaux, Bordeaux, France.
¹⁹ Department of Anesthesia and Critical Care Medicine CHRU Nancy, Nancy.

PMID: 37178818
DOI: 10.1016/j.accpm.2023.101241

No abstract available

Keywords: Cesarean delivery; Postpartum hemorrhage; Tranexamic acid.

Publication types

Editorial

MeSH terms

Antifibrinolytic Agents* / therapeutic use
Female
Humans
Postpartum Hemorrhage* / prevention & control
Pregnancy
Tranexamic Acid* / therapeutic use

Substances

Tranexamic Acid
Antifibrinolytic Agents