Five undescribed guanidine alkaloids from Plumbago zeylanica

Liu Zheng; Peng-Ju Guo; Yao Zhu; Chen-Yue Li; Wen-Qiong Wang; Li-Jiang Xuan

doi:10.1016/j.fitote.2023.105538

Five undescribed guanidine alkaloids from Plumbago zeylanica

Fitoterapia. 2023 Jul:168:105538. doi: 10.1016/j.fitote.2023.105538. Epub 2023 May 11.

Authors

Liu Zheng¹, Peng-Ju Guo², Yao Zhu¹, Chen-Yue Li¹, Wen-Qiong Wang³, Li-Jiang Xuan⁴

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China. Electronic address: wenqiong1019@126.com.
⁴ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China. Electronic address: ljxuan@simm.ac.cn.

PMID: 37178808
DOI: 10.1016/j.fitote.2023.105538

Abstract

Five undescribed guanidine alkaloids, plumbagines HK (1-4) and plumbagoside E (5), as well as five known analogues (6-10) were isolated from the roots of Plumbago zeylanica. Their structures were established by extensive spectroscopic analyses and chemical methods. In addition, 1-10 were accessed their anti-inflammatory activities by measuring nitric oxide (NO) concentrations in LPS-induced RAW 264.7 cells. However, all compounds especially 1 and 3-5 could not inhibit the secretion of NO but significant increase the secretion of NO. The result reminded us that 1-10 may become potential novel immune potentiators.

Keywords: Guanidine alkaloids; Plumbaginaceae; Plumbago zeylanica.

MeSH terms

Alkaloids* / chemistry
Alkaloids* / isolation & purification
Alkaloids* / pharmacology
Animals
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology
Guanidines / chemistry
Guanidines / isolation & purification
Guanidines / pharmacology
Macrophages / drug effects
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide / metabolism
Plant Roots / chemistry
Plumbaginaceae* / chemistry
RAW 264.7 Cells

Substances

Alkaloids
Guanidines
Anti-Inflammatory Agents
Nitric Oxide