Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides

Yukihito Higashi

doi:10.3390/cells12091293

Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides

Cells. 2023 May 1;12(9):1293. doi: 10.3390/cells12091293.

Author

Yukihito Higashi^{1

2}

Affiliations

¹ Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 743-8551, Japan.
² Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8553, Japan.

Abstract

Dyslipidemia is associated with endothelial dysfunction. Endothelial dysfunction is the initial step for atherosclerosis, resulting in cardiovascular complications. It is clinically important to break the process of endothelial dysfunction to cardiovascular complications in patients with dyslipidemia. Lipid-lowering therapy enables the improvement of endothelial function in patients with dyslipidemia. It is likely that the relationships of components of a lipid profile such as low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides with endothelial function are not simple. In this review, we focus on the roles of components of a lipid profile in endothelial function.

Keywords: dyslipidemia; endothelial function; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; triglycerides.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Atherosclerosis* / complications
Cholesterol, HDL
Cholesterol, LDL
Dyslipidemias*
Humans
Triglycerides

Substances

Triglycerides
Cholesterol, HDL
Cholesterol, LDL

Associated data

UMIN-CTR/UMIN000012950

Grants and funding

This work was supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (18590815 and 21590898 to Y.H.) and a Grant-in-Aid of Japanese Arteriosclerosis Prevention Fund (to Y.H.).