The VGNC: expanding standardized vertebrate gene nomenclature

Tamsin E M Jones; Bethan Yates; Bryony Braschi; Kristian Gray; Susan Tweedie; Ruth L Seal; Elspeth A Bruford

doi:10.1186/s13059-023-02957-2

The VGNC: expanding standardized vertebrate gene nomenclature

Genome Biol. 2023 May 12;24(1):115. doi: 10.1186/s13059-023-02957-2.

Authors

Tamsin E M Jones¹, Bethan Yates^{2

3}, Bryony Braschi², Kristian Gray^{2

4}, Susan Tweedie², Ruth L Seal^{2

4}, Elspeth A Bruford^{2

4}

Affiliations

¹ HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK. tjones@ebi.ac.uk.
² HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
³ Current address: Tree of Life, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, Cambridgeshire, UK.
⁴ Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, Cambridgeshire, UK.

Abstract

The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 as a sister project to the HUGO Gene Nomenclature Committee, to approve gene nomenclature in vertebrate species without an existing dedicated nomenclature committee. The VGNC aims to harmonize gene nomenclature across selected vertebrate species in line with human gene nomenclature, with orthologs assigned the same nomenclature where possible. This article presents an overview of the VGNC project and discussion of key findings resulting from this work to date. VGNC-approved nomenclature is accessible at https://vertebrate.genenames.org and is additionally displayed by the NCBI, Ensembl, and UniProt databases.

Keywords: Comparative genomics; Gene families; Gene nomenclature; Gene symbols; Homology; Orthology; Vertebrates.

The VGNC: expanding standardized vertebrate gene nomenclature

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Abstract

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