Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Pathol Res Pract. 2023 Jun:246:154512. doi: 10.1016/j.prp.2023.154512. Epub 2023 May 8.

Abstract

Long non-coding RNAs (lncRNAs) are a class of noncoding RNAs with a length larger than 200 nucleotides that participate in various diseases and biological processes as they can control gene expression by different mechanisms. Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder characterized by symmetrical destructive destruction of distal joints as well as extra-articular involvement. Different studies have documented and proven the abnormal expression of lncRNAs in RA patients. Various lncRNAs have proven potential as biomarkers and targets for diagnosing, prognosis and treating RA. This review will focus on RA pathogenesis, clinical implications, and related lncRNA expressions that help to identify new biomarkers and treatment targets.

Keywords: Clinical implications; Long non-coding RNAs (lncRNAs); Pathogenesis; Rheumatoid arthritis (RA).

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid* / genetics
  • Arthritis, Rheumatoid* / metabolism
  • Arthritis, Rheumatoid* / pathology
  • Biomarkers / metabolism
  • Humans
  • RNA, Long Noncoding* / genetics
  • RNA, Untranslated

Substances

  • RNA, Long Noncoding
  • RNA, Untranslated
  • Biomarkers