1 Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
2 Institute of Clinical Trials and Methodology, University College London, London, UK.
3 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and University of Milan, Milan, Italy. piermannuccio.mannucci@policlinico.mi.it.