Research progress of E3 ubiquitin ligase regulating biological behavior of human placental trophoblast cells

Jun Feng; Huimei Yin; Baturuhu; Yonghui Dai; Fuxiao Dai; Junjun Xu; Zhili Chen; Yanyan Liu

doi:10.3389/fendo.2023.1124041

Research progress of E3 ubiquitin ligase regulating biological behavior of human placental trophoblast cells

Front Endocrinol (Lausanne). 2023 Apr 14:14:1124041. doi: 10.3389/fendo.2023.1124041. eCollection 2023.

Authors

Jun Feng¹, Huimei Yin², Baturuhu³, Yonghui Dai⁴, Fuxiao Dai⁴, Junjun Xu⁴, Zhili Chen⁴, Yanyan Liu⁵

Affiliations

¹ Department of Emergency Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
² Department of Emergency Medicine, People's Hospital of Bortala Mongol Autonomous Prefecture, Bole, China.
³ Department of Neurosurgery Intensive Care Unit (ICU), People's Hospital of Bortala Mongol Autonomous Prefecture, Bole, China.
⁴ Obstetrics Department, People's Hospital of Bortala Mongol Autonomous Prefecture, Bole, China.
⁵ Obstetrics and Gynecology Department, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Abstract

E3 ubiquitin ligases are important components of the ubiquitin protease system. This family includes many proteins, which can catalyze the ubiquitination of a variety of protein substrates and promote the degradation of them by the proteasome system. Recent studies have shown that E3 ubiquitin ligase plays a key role in the process of fetal development and placental formation. It affects the biological behavior of placental trophoblast cells, leading to a series of pregnancy complications that threaten mothers and babies greatly. This review focuses on the regulation, target and mechanism of E3 ubiquitin ligase on the biological behavior of human placental trophoblast cells.

Keywords: E3 ubiquitin ligase; apoptosis; human trophoblast cells; in vitro migration; invasiveness; pregnancy complications; proliferation and differentiation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Placenta / metabolism
Pregnancy
Trophoblasts* / metabolism
Ubiquitin / metabolism
Ubiquitin-Protein Ligases* / genetics
Ubiquitination

Substances

Ubiquitin-Protein Ligases
Ubiquitin

Grants and funding

This work was supported by grants from Foundation Project of China International Medical Exchange Foundation (grant no. z-2016-23-2101-04), Natural Science Foundation of Hubei Province (grant no. 2020CFB577), Hubei Provincial Health Commission Fund Project (grant no. WJ2023M022), and Foundation Project of Natural Science Foundation of Xinjiang Uygur Autonomous Region (grant no. 2022D01F65).