Four-part harmony between diet, drugs, microbes, and host

Patrick H Bradley

doi:10.1016/j.chom.2023.04.013

Four-part harmony between diet, drugs, microbes, and host

Cell Host Microbe. 2023 May 10;31(5):689-691. doi: 10.1016/j.chom.2023.04.013.

Author

Patrick H Bradley¹

Affiliation

¹ Department of Microbiology, The Ohio State University, Columbus, OH 43201, USA; Infectious Diseases Institute, The Ohio State University, Columbus, OH 43201, USA. Electronic address: bradley.720@osu.edu.

PMID: 37167950
DOI: 10.1016/j.chom.2023.04.013

Abstract

In this issue of Cell Host & Microbe, Zeng et al. show that a specific gut microbe causes diet-dependent attenuation of acetaminophen toxicity in mice. This link between gut microbes and toxicity is mechanistically detailed, yet intriguingly indirect, mediated by the transformation of ingested phytochemicals as opposed to the drug itself.

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