Reconfigurable Two-Dimensional DNA Molecular Arrays

Donglei Yang; Fan Xu; Pengfei Wang

doi:10.1007/978-1-0716-3028-0_4

Reconfigurable Two-Dimensional DNA Molecular Arrays

Methods Mol Biol. 2023:2639:69-81. doi: 10.1007/978-1-0716-3028-0_4.

Authors

Donglei Yang¹, Fan Xu¹, Pengfei Wang²

Affiliations

¹ Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao, Tong University, Shanghai, China.
² Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao, Tong University, Shanghai, China. pengfei.wang@sjtu.edu.cn.

PMID: 37166711
DOI: 10.1007/978-1-0716-3028-0_4

Abstract

In biology, molecular cascade signaling is an essential tool to mediate various pathways and downstream behaviors. Mimicking these molecular cascades plays an important role in synthetic biology. The use of DNA self-assembly represents an elegant way to build sophisticated molecular cascades. For instance, a DNA molecular array connected by a number of dynamic anti-junction units was able to realize prescribed, multistep, long-range cascaded transformation. The dynamic DNA molecular array is able to execute transformations with programmable initiation, propagation, and regulation. The transformation of the array can be initiated at selected units and then propagated, without addition of extra triggers, to neighboring units and eventually the entire array.

Keywords: Cascaded transformation; DNA nanostructure; Reconfigurable 2D arrays; Self-assembly.

MeSH terms

DNA* / genetics
Nanotechnology* / methods
Oligonucleotide Array Sequence Analysis / methods

Substances

DNA