Magnetic Resonance-Guided focused ultrasound surgery for Parkinson's disease: A mini-review and comparison between deep brain stimulation

Tzu-Hsiang Ko; Yu-Hsuan Lee; Lung Chan; Kevin Wen-Kai Tsai; Chien-Tai Hong; Wei-Lun Lo

doi:10.1016/j.parkreldis.2023.105431

Magnetic Resonance-Guided focused ultrasound surgery for Parkinson's disease: A mini-review and comparison between deep brain stimulation

Parkinsonism Relat Disord. 2023 Jun:111:105431. doi: 10.1016/j.parkreldis.2023.105431. Epub 2023 May 5.

Authors

Tzu-Hsiang Ko¹, Yu-Hsuan Lee², Lung Chan¹, Kevin Wen-Kai Tsai³, Chien-Tai Hong⁴, Wei-Lun Lo⁵

Affiliations

¹ Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan.
² Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan; Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
³ InSightec Ltd, Tirat Carmel, Israel.
⁴ Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. Electronic address: ct.hong@tmu.edu.tw.
⁵ Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan; Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: 12317@s.tmu.edu.tw.

PMID: 37164870
DOI: 10.1016/j.parkreldis.2023.105431

Abstract

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson's disease (PD). Previous experience with radiofrequency lesionectomy and deep brain stimulation (DBS) has identified several candidate targets for MRgFUS intended to alleviate the motor symptoms of PD. The main advantage of MRgFUS is that it is incisionless. MRgFUS has certain limitations and is associated with adverse effects. The present study reviews the literature on conventional surgical interventions for PD, discusses recent studies on MRgFUS, and the comparison between DBS and MRgFUS for PD. The reviews aims to provide an essential reference for neurologists to select the appropriate treatments for patients with PD.

Keywords: Deep brain stimulation; Magnetic resonance–guided focused ultrasound surgery; Parkinson's disease.

Publication types

Review

MeSH terms

Deep Brain Stimulation*
Essential Tremor* / therapy
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Parkinson Disease* / diagnostic imaging
Parkinson Disease* / surgery
Treatment Outcome
Ultrasonic Surgical Procedures*