CCL13 and human diseases

Laifu Li; Fei Dai; Lianli Wang; Yating Sun; Lin Mei; Yan Ran; Fangchen Ye

doi:10.3389/fimmu.2023.1176639

CCL13 and human diseases

Front Immunol. 2023 Apr 19:14:1176639. doi: 10.3389/fimmu.2023.1176639. eCollection 2023.

Authors

Laifu Li^{1

2}, Fei Dai^{1

2}, Lianli Wang^{1

2}, Yating Sun^{1

2}, Lin Mei^{1

2}, Yan Ran^{1

2}, Fangchen Ye^{1

2}

Affiliations

¹ Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
² Shaanxi Province Key Laboratory of Gastrointestinal Motility Disorders, Laboratory of Digestive Diseases of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Abstract

CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many immune cells. Despite extensive research into its function in numerous disorders, a thorough analysis of CCL13 is not yet accessible. The role of CCL13 in human disorders and existing CCL13-focused therapies are outlined in this study. The function of CCL13 in rheumatic diseases, skin conditions, and cancer is comparatively well-established, and some studies also suggest that it may be involved in ocular disorders, orthopedic conditions, nasal polyps, and obesity. We also give an overview of research that found very little evidence of CCL13 in HIV, nephritis, and multiple sclerosis. Even though CCL13-mediated inflammation is frequently linked to disease pathogenesis, it's fascinating to note that in some conditions, like primary biliary cholangitis (PBC) and suicide, it might even act as a preventative measure.

Keywords: CCL13; MCP-4; NF-κB; Th2; cytokines; human diseases; type 2 immunity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chemokines, CC*
Humans
Monocyte Chemoattractant Proteins*

Substances

Chemokines, CC
CCL13 protein, human
Monocyte Chemoattractant Proteins

Grants and funding

This study was supported by the National Natural Science Foundation of China (NO. 81770540), and the Key Research and Development Project of Shaanxi Province (NO. 2020SF235).