Functional insights to the development of bioactive material for combating bacterial infections

Duoyang Fan; Xiaohui Liu; Yueming Ren; Shuaige Bai; Yanbing Li; Ziheng Luo; Jie Dong; Fei Chen; Wenbin Zeng

doi:10.3389/fbioe.2023.1186637

Functional insights to the development of bioactive material for combating bacterial infections

Front Bioeng Biotechnol. 2023 Apr 21:11:1186637. doi: 10.3389/fbioe.2023.1186637. eCollection 2023.

Authors

Duoyang Fan^{1

2}, Xiaohui Liu^{1

2}, Yueming Ren^{1

2}, Shuaige Bai^{1

2}, Yanbing Li³, Ziheng Luo^{1

2}, Jie Dong^{1

2}, Fei Chen^{1

2}, Wenbin Zeng^{1

2}

Affiliations

¹ Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
² Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, China.
³ Xiangya Hospital, Central South University, Changsha, China.

Abstract

The emergence of antibiotic-resistant "superbugs" poses a serious threat to human health. Nanomaterials and cationic polymers have shown unprecedented advantages as effective antimicrobial therapies due to their flexibility and ability to interact with biological macromolecules. They can incorporate a variety of antimicrobial substances, achieving multifunctional effects without easily developing drug resistance. Herein, this article discusses recent advances in cationic polymers and nano-antibacterial materials, including material options, fabrication techniques, structural characteristics, and activity performance, with a focus on their fundamental active elements.

Keywords: antibacterial; cationic polymers; multidrug-resistant bacterial biofilm; nanomaterials; theranostics.

Publication types

Review