Editorial: Immunological imbalance: What is its role in intervertebral disc degeneration?

Front Cell Dev Biol. 2023 Apr 20:11:1196377. doi: 10.3389/fcell.2023.1196377. eCollection 2023.

Benjamin Gantenbein^{1

2}, Zhen Sun³, Zhongyang Liu⁴, Dino Samartzis⁵

¹ Tissue Engineering for Orthopaedics and Mechanobiology, Bone and Joint Program, Department for BioMedical Research (DBMR) of the Medical Faculty, University of Bern, Bern, Switzerland.
² Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Medical Faculty, University of Bern, Bern, Switzerland.
³ Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
⁴ Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
⁵ Rush Medical College, Rush University, Chicago, IL, United States.

No abstract available

Keywords: IL17; immune cells; intervertebral disc; low back pain; macrophages; miRNA; single-cell RNA-seq.

Publication types

BG wishes to acknowledge his funding sources, namely, the Marie Skłodowska Curie International Training Network (ITN) “disc4all” (https://disc4all.upf.edu, accessed on 22 March 2023) grant agreement #955735 (https://cordis.europa.eu/project/id/955735, accessed on 22 March 2023), the iPSpine project (https://ipspine.eu, accessed 17 April 2023) under the grant agreement #825925 (https://cordis.europa.eu/project/id/825925, accessed 17 April 2023) and the Swiss National Science Foundation projects #310030E_192674/1 (https://data.snf.ch/grants/grant/192674, accessed on 23 March 2023) and project #40B2-0_211510/1 (https://data.snf.ch/grants/grant/211510, accessed on 23 March 2023). ZS acknowledges the National Natural Science Foundation of China (grant #82002348).