UXT at the crossroads of cell death, immunity and neurodegenerative diseases

Pengzhe Han; Shaojian Mo; Zhengwang Wang; Jiale Xu; Xifeng Fu; Yanzhang Tian

doi:10.3389/fonc.2023.1179947

UXT at the crossroads of cell death, immunity and neurodegenerative diseases

Front Oncol. 2023 Apr 19:13:1179947. doi: 10.3389/fonc.2023.1179947. eCollection 2023.

Authors

Pengzhe Han¹, Shaojian Mo^{1

2}, Zhengwang Wang¹, Jiale Xu¹, Xifeng Fu^{1

2}, Yanzhang Tian^{1

2}

Affiliations

¹ Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, China.
² Department of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.

Abstract

The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance.

Keywords: UXT; apoptosis; autophagy; immunity; neurodegenerative disease.

Publication types

Review

Grants and funding

This article was supported by Shanxi Provincial Department of Human Resources and Social Security, grant number 20210002; Shanxi Province 136 revitalization medical project (department of general surgery)