Gelatinous lanthanide coordination polymer with aggregation-enhanced antenna effect for ratiometric detection of endogenous alkaline phosphatase

Huifang Wu; Shiying Ju; Yuwei Ling; Haozhe Sun; Yanfeng Tang; Changlun Tong

doi:10.1016/j.jcis.2023.04.147

Gelatinous lanthanide coordination polymer with aggregation-enhanced antenna effect for ratiometric detection of endogenous alkaline phosphatase

J Colloid Interface Sci. 2023 Sep:645:338-349. doi: 10.1016/j.jcis.2023.04.147. Epub 2023 May 3.

Authors

Huifang Wu¹, Shiying Ju², Yuwei Ling², Haozhe Sun², Yanfeng Tang³, Changlun Tong⁴

Affiliations

¹ Nantong Key Lab of Intelligent and New Energy Materials, School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. Electronic address: whf0125@ntu.edu.cn.
² Nantong Key Lab of Intelligent and New Energy Materials, School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China.
³ Nantong Key Lab of Intelligent and New Energy Materials, School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. Electronic address: tangyf@ntu.edu.cn.
⁴ Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: cltong@zju.edu.cn.

PMID: 37150007
DOI: 10.1016/j.jcis.2023.04.147

Abstract

Aggregation-induced emission (AIE) and antenna effect (AE) are two significant behaviors that have attracted increasing attention. However, it is challenging to achieve the synergistic effect of AIE and AE in luminescent materials for more extensive applications. Here, four gelatinous Ln³⁺ coordination polymers (Ln-CPs) are synthesized by self-assembly of ciprofloxacin (CIP), adenosine monophosphate (AMP), and Ln³⁺ ions in aqueous medium. Encouragingly, a remarkable increase in the characteristic fluorescence of Ln³⁺ and a significant decrease in CIP are observed along with increasing concentration of Ln-CPs, which is attributed to the large aggregates formed by self-assembly that strictly constrain the intramolecular motions of antenna ligands, thereby achieving the aggregation-enhanced AE. More meaningfully, Eu-CP not only shows a rice-like morphology at high aggregation state, but also provides an opportunity for the selective detection of alkaline phosphatase (ALP). A new flower-like polymer is formed upon incubating Eu-CP with ALP, accompanied by the fluorescence quenching of Eu³⁺ and recovery of CIP, a ratiometric determination of ALP in the range of 0.1-6.0 U·L^-1 is thus achieved. Additionally, ALP assay in human serum and bioimaging in living cells have been successfully performed. This research opens a new horizon for the fabrication of Ln³⁺-based luminescent materials with promising applications.

Keywords: Aggregation-induced emission; Alkaline phosphatase; Antenna effect; Ratiometric.

MeSH terms

Alkaline Phosphatase*
Fluorescent Dyes
Humans
Ions
Lanthanoid Series Elements*
Polymers

Substances

Alkaline Phosphatase
Lanthanoid Series Elements
Polymers
Fluorescent Dyes
Ions