Current Concepts in Nodal Peripheral T-Cell Lymphomas

Naoki Oishi; Andrew L Feldman

doi:10.1016/j.path.2023.01.011

Current Concepts in Nodal Peripheral T-Cell Lymphomas

Surg Pathol Clin. 2023 Jun;16(2):267-285. doi: 10.1016/j.path.2023.01.011. Epub 2023 Apr 3.

Authors

Naoki Oishi¹, Andrew L Feldman²

Affiliations

¹ Department of Pathology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: feldman.andrew@mayo.edu.

PMID: 37149360
DOI: 10.1016/j.path.2023.01.011

Abstract

This review summarizes the current understanding of mature T-cell neoplasms predominantly involving lymph nodes, including ALK-positive and ALK-negative anaplastic large cell lymphomas, nodal T-follicular helper cell lymphoma, Epstein-Barr virus-positive nodal T/NK-cell lymphoma, and peripheral T-cell lymphoma (PTCL), not otherwise specified. These PTCLs are clinically, pathologically, and genetically heterogeneous, and the diagnosis is made by a combination of clinical information, morphology, immunophenotype, viral positivity, and genetic abnormalities. This review summarizes the pathologic features of common nodal PTCLs, highlighting updates in the fifth edition of the World Health Organization classification and the 2022 International Consensus Classification.

Keywords: Anaplastic large cell lymphoma; Epstein-Barr virus–positive nodal T/NK-cell lymphoma; Peripheral T-cell lymphoma; T-follicular helper cell lymphoma.

Publication types

Review

MeSH terms

Epstein-Barr Virus Infections* / diagnosis
Epstein-Barr Virus Infections* / pathology
Herpesvirus 4, Human / genetics
Humans
Lymph Nodes / pathology
Lymphoma, T-Cell, Peripheral* / diagnosis
Lymphoma, T-Cell, Peripheral* / genetics
Lymphoma, T-Cell, Peripheral* / pathology
Receptor Protein-Tyrosine Kinases

Substances

Receptor Protein-Tyrosine Kinases