Biosensors for prostate cancer detection

Sattar Akbari Nakhjavani; Begum K Tokyay; Cansu Soylemez; Misagh R Sarabi; Ali K Yetisen; Savas Tasoglu

doi:10.1016/j.tibtech.2023.04.001

Biosensors for prostate cancer detection

Trends Biotechnol. 2023 Oct;41(10):1248-1267. doi: 10.1016/j.tibtech.2023.04.001. Epub 2023 May 3.

Authors

Sattar Akbari Nakhjavani¹, Begum K Tokyay², Cansu Soylemez³, Misagh R Sarabi⁴, Ali K Yetisen⁵, Savas Tasoglu⁶

Affiliations

¹ Department of Mechanical Engineering, Koç University, Sariyer, Istanbul 34450, Turkey; Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey.
² Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey; Department of Biomedical Sciences and Engineering, Koç University, 34450 Istanbul, Turkey.
³ Department of Biomedical Sciences and Engineering, Koç University, 34450 Istanbul, Turkey.
⁴ Department of Biomedical Sciences and Engineering, Koç University, 34450 Istanbul, Turkey; Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, Germany 70569.
⁵ Department of Chemical Engineering, Imperial College, London SW7 2AZ, UK.
⁶ Department of Mechanical Engineering, Koç University, Sariyer, Istanbul 34450, Turkey; Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey; Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, Germany 70569; Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University, Istanbul 34450, Turkey; Boğaziçi Institute of Biomedical Engineering, Boğaziçi University, Istanbul 34684, Turkey. Electronic address: stasoglu@ku.edu.tr.

PMID: 37147246
DOI: 10.1016/j.tibtech.2023.04.001

Abstract

Prostate cancer (PC) is one of the most common tumors and a leading cause of mortality among men, resulting in ~375 000 deaths annually worldwide. Various analytical methods have been designed for quantitative and rapid detection of PC biomarkers. Electrochemical (EC), optical, and magnetic biosensors have been developed to detect tumor biomarkers in clinical and point-of-care (POC) settings. Although POC biosensors have shown potential for detection of PC biomarkers, some limitations, such as the sample preparation, should be considered. To tackle such shortcomings, new technologies have been utilized for development of more practical biosensors. Here, biosensing platforms for the detection of PC biomarkers such as immunosensors, aptasensors, genosensors, paper-based devices, microfluidic systems, and multiplex high-throughput platforms, are discussed.

Keywords: biomarkers; biosensors; healthcare; point of care; prostate cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Biosensing Techniques* / methods
Electrochemical Techniques
Humans
Immunoassay
Male
Point-of-Care Systems
Prostatic Neoplasms* / diagnosis

Substances

Biomarkers, Tumor