Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications

Assaf Zinger

doi:10.1016/j.jconrel.2023.04.040

Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications

J Control Release. 2023 Jun:358:591-600. doi: 10.1016/j.jconrel.2023.04.040. Epub 2023 May 22.

Author

Assaf Zinger¹

Affiliation

¹ Laboratory for Bioinspired Nano Engineering and Translational Therapeutics, Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel; Cardiovascular Sciences Department, Houston Methodist Academic Institute, Houston, TX 77030, United States; Neurosurgery Department, Houston Methodist Academic Institute, Houston, TX 77030, United States. Electronic address: assafzinger@technion.ac.il.

PMID: 37146767
DOI: 10.1016/j.jconrel.2023.04.040

Abstract

In this contribution to the Orations - New Horizons of the Journal of Controlled Release, I present design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. I furthermore describe BNP fabrication methods and analyze their advantages and challenges. Finally, I suggest future therapeutic applications of each BNP group and propose a new revolutionary concept for their use.

Keywords: Biomimetic nanoparticles; Cell membrane; Drug delivery; Nanomedicine; Translational therapeutics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials*
Biomimetics / methods
Cell Membrane / metabolism
Drug Delivery Systems / methods
Membrane Proteins / metabolism
Nanoparticles*

Substances

Membrane Proteins