Breathing-induced forces influence lung cell fate

Min-Chi Yang; Martha G Rea-Moreno; Ya-Wen Chen

doi:10.1016/j.stem.2023.04.004

Breathing-induced forces influence lung cell fate

Cell Stem Cell. 2023 May 4;30(5):507-508. doi: 10.1016/j.stem.2023.04.004.

Authors

Min-Chi Yang¹, Martha G Rea-Moreno², Ya-Wen Chen³

Affiliations

¹ Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Institute for Airway Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Center for Epithelial and Airway Biology and Regeneration, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
² Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Institute for Airway Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Center for Epithelial and Airway Biology and Regeneration, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Master of Science in Biomedical Science Program, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
³ Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Institute for Airway Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Center for Epithelial and Airway Biology and Regeneration, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. Electronic address: yawen.chen@mssm.edu.

PMID: 37146577
DOI: 10.1016/j.stem.2023.04.004

Abstract

Respiration exerts a mechanical strain on the lungs, which has an unclear effect on epithelial cell fate. Now in Cell, Shiraishi et al.¹ reveal the crucial role of mechanotransduction in maintaining lung epithelial cell fate, representing a significant milestone in understanding how mechanical factors regulate differentiation.

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MeSH terms

Cell Differentiation / physiology
Epithelial Cells
Lung* / physiology
Mechanotransduction, Cellular* / physiology
Respiration