The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Giulia Sgueglia; Salvatore Longobardi; Domenico Valerio; Maria Rosaria Campitiello; Nicola Colacurci; Cinzia Di Pietro; Rosalia Battaglia; Thomas D'Hooghe; Lucia Altucci; Carmela Dell'Aversana

doi:10.1186/s13148-023-01490-0

The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Clin Epigenetics. 2023 May 4;15(1):76. doi: 10.1186/s13148-023-01490-0.

Authors

Giulia Sgueglia^#¹, Salvatore Longobardi^#², Domenico Valerio³, Maria Rosaria Campitiello⁴, Nicola Colacurci^{3

5}, Cinzia Di Pietro⁶, Rosalia Battaglia⁶, Thomas D'Hooghe², Lucia Altucci^#^{7

8

9}, Carmela Dell'Aversana^#^{10

11}

Affiliations

¹ Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy.
² Merck KGaA, 64293, Darmstadt, Germany.
³ Outpatient Fertility Unit, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy.
⁴ Department of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno, Salerno, Italy.
⁵ Department of Woman, Child and General and Special Surgery, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy.
⁶ Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics "Giovanni Sichel", University of Catania, 95123, Catania, CT, Italy.
⁷ Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy. lucia.altucci@unicampania.it.
⁸ BIOGEM, Ariano Irpino, Italy. lucia.altucci@unicampania.it.
⁹ Institute of Experimental Endocrinology and Oncology 'Gaetano Salvatore' (IEOS)-National Research Council (CNR), Naples, Italy. lucia.altucci@unicampania.it.
¹⁰ Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy. carmela.dellaversana@cnr.it.
¹¹ Institute of Experimental Endocrinology and Oncology 'Gaetano Salvatore' (IEOS)-National Research Council (CNR), Naples, Italy. carmela.dellaversana@cnr.it.

^# Contributed equally.

Abstract

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.

Keywords: Epigenetics; Fertility; IVF; Reproduction.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aged
DNA Methylation*
Female
Fertility
Fertilization in Vitro / adverse effects
Humans
Infertility, Female* / genetics
Infertility, Female* / therapy
Pregnancy
Pregnancy Rate