The Beck Depression Inventory-II (BDI-II) is used to assess depression with people from many cultures and ethnicities; however, the scale has been validated with very few populations other than the majority (Gray et al., 2016). Secondary analysis of data included two-factor confirmatory factor analyses (CFA) of the BDI-II with two independent American Indian samples, which were compared with the results in the BDI-II Manual (Beck et al., 1996). Sample 1 included 527 adult American Indians recruited from seven tribal communities, and Sample 2 included a community sample of 440 American Indian adults. The results of both CFA matched the original factor structure reported in Beck et al. (1996) supporting the construct validity of the BDI-II in Northern Plains American Indians. The internal consistency of the BDI-II was very high in Sample 1 (r = .94) but somewhat lower in Sample 2 (r = .72). Measures of convergent validity and discriminant validity were below acceptability for both Sample 1 and Sample 2. The results of this study support the construct validity of the BDI-II in Northern Plains American Indians. (PsycInfo Database Record (c) 2023 APA, all rights reserved).