[Surface modification of multifunctional ferrite magnetic nanoparticles and progress in biomedicine]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Apr 25;40(2):378-383. doi: 10.7507/1001-5515.202209056.
[Article in Chinese]

Abstract

Magnetic ferrite nanoparticles (MFNPs) have great application potential in biomedical fields such as magnetic resonance imaging, targeted drugs, magnetothermal therapy and gene delivery. MFNPs can migrate under the action of a magnetic field and target specific cells or tissues. However, to apply MFNPs to organisms, further modifications on the surface of MFNPs are required. In this paper, the common modification methods of MFNPs are reviewed, their applications in medical fields such as bioimaging, medical detection, and biotherapy are summarized, and the future application directions of MFNPs are further prospected.

铁氧体磁性纳米材料(MFNPs)在生物医学领域具有较大应用潜力,如磁共振成像、靶向递药、磁热治疗、基因递送等。MFNPs能够在磁场作用下发生迁移运动,并靶向定位到目标细胞或组织。但是要将MFNPs应用到生物体内,需进一步在MFNPs表面进行修饰。本文对MFNPs常见的修饰方法进行了综述,并总结了它在生物成像、医学检测以及生物治疗等医学领域中的应用,进一步展望了MFNPs的未来应用方向。.

Keywords: Bioimaging; Biotherapy; Ferrite; Targeting.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Ferric Compounds
  • Magnetic Resonance Imaging / methods
  • Magnetics
  • Magnetite Nanoparticles* / therapeutic use
  • Nanoparticles*

Substances

  • Ferric Compounds
  • ferrite
  • Magnetite Nanoparticles

Grants and funding

新疆维吾尔自治区自然科学基金项目(2021D01C293);企业委托项目(H04W201146);国家自然科学基金(82202220)