Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

Ravibhai Bhola; Rizwan Ghumara; Chirag Patel; Vyomesh Parsana; Keyur Bhatt; Dinesh Kundariya; Hasit Vaghani

doi:10.1021/acsomega.2c07877

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

ACS Omega. 2023 Apr 14;8(16):14430-14439. doi: 10.1021/acsomega.2c07877. eCollection 2023 Apr 25.

Authors

Ravibhai Bhola¹, Rizwan Ghumara², Chirag Patel³, Vyomesh Parsana⁴, Keyur Bhatt¹, Dinesh Kundariya², Hasit Vaghani¹

Affiliations

¹ Department of Chemistry, Ganpat University, Kherva 384012, Gujarat, India.
² Department of Chemistry, Tolani College of Arts and Sciences, Adipur 370205, Gujarat, India.
³ Department of Chemistry, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj 370001, Gujarat, India.
⁴ Chemical Engineering Department, VVP Engineering College, Gujarat Technological University, Rajkot 360005, Gujarat, India.

Abstract

Benzethonium chloride (BTC) has various applications in several industries. The solubility and solution thermodynamic properties of BTC were measured. The solubility of BTC in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, water, dimethyl sulfoxide, acetic acid, and dimethyl formamide neat solvents and methanol + water and ethanol + water binary solvents at 298.15-318.15 K over an atmospheric pressure was measured. The solubility data of BTC is positively related to the temperature in all selected solvents. The solubility data was fitted by the Apelblat model, λh model, Yaws model, Van't Hoff equation, CNIBS/R-K model, and modified Jouyban-Acree equation. The RMSD and ARD were chosen to evaluate the fitting of each model. The dissolution thermodynamic parameters, enthalpy of the solution, entropy of the solution, and Gibbs energy of the solution were calculated. The solubility data and dissolution thermodynamic parameters of BTC will provide significant guidance for purification, crystallization, and separation in various areas.