Association of Dietary intake of vitamin E with chronic obstructive pulmonary disease events in US adults: A cross-sectional study of NHANES 2013-2018

Ziyi Liu; Yingjie Su; Qing Chen; Lihua Xiao; Xue Zhao; Feichi Wang; Zhenyu Peng; Hongliang Zhang

doi:10.3389/fnut.2023.1124648

Association of Dietary intake of vitamin E with chronic obstructive pulmonary disease events in US adults: A cross-sectional study of NHANES 2013-2018

Front Nutr. 2023 Apr 12:10:1124648. doi: 10.3389/fnut.2023.1124648. eCollection 2023.

Authors

Ziyi Liu¹, Yingjie Su¹, Qing Chen¹, Lihua Xiao¹, Xue Zhao², Feichi Wang¹, Zhenyu Peng¹, Hongliang Zhang¹

Affiliations

¹ Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² College of Medicine, Hunan Normal University, Changsha, China.

Abstract

Introduction: Several studies have demonstrated that vitamin E intake is negatively associated with the development of several diseases, but the relationship between vitamin E intake and COPD in different groups of people is not clear. The aim was to investigate the relationship between vitamin E intake and COPD in different groups of people.

Methods: This study used data from NHANES (National Health and Nutrition Examination Survey) from 2013-2018. A final total of 4,706 participants were included, univariate versus multivariate logistic regression and restricted cubic spline models adjusted for confounders were used to explore the relationship between vitamin E intake and COPD, and subgroup analyses were conducted to assess whether there are differences in the relationship between vitamin E intake and COPD in different populations or conditions.

Results: After adjusting for potential confounders, higher vitamin E intake showed a significant negative association with COPD [Model 1(unadjusted covariates, OR = 0.48;95% CI:0.33-0.70; p < 0.001), Model 2(adjusted for age, sex, and race, OR = 0.48;95% CI:0.31-0.73; p < 0.01), and Model 3(adjusted for all covariates, OR = 0.57;95% CI:0.36-0.91; p = 0.02)]. And a restricted cubic spline curve showed a significant negative correlation between vitamin E intake and COPD (p for nonlinear = 0.2036). In the subgroup analysis, we found a negative association between vitamin E intake and COPD in all subgroups as well.

Conclusion: After analyzing data based on the NHANES database from 2013-2018, the results showed that vitamin E intake among U.S. adults was well below the recommended levels and that higher vitamin E intake was negatively associated with COPD incidence.

Keywords: COPD; NHANES; cross-sectional studies; subgroups; vitamin E.