Genetic loss-of-function does not support gain-of-function studies suggesting retinoic acid controls limb bud timing and scaling

Marie Berenguer; Gregg Duester

doi:10.3389/fcell.2023.1149009

Genetic loss-of-function does not support gain-of-function studies suggesting retinoic acid controls limb bud timing and scaling

Front Cell Dev Biol. 2023 Apr 13:11:1149009. doi: 10.3389/fcell.2023.1149009. eCollection 2023.

Authors

Marie Berenguer¹, Gregg Duester¹

Affiliation

¹ Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.

No abstract available

Keywords: gain-of-function; genetic loss-of-function; limb development; limb patterning; retinoic acid signaling.

Grants and funding

This work was funded by the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases) grant R56 AR067731 (GD).