Catalytic utilization of converter gas - an industrial waste for the synthesis of pharmaceuticals

Chem Sci. 2023 Mar 31;14(16):4346-4350. doi: 10.1039/d3sc00257h. eCollection 2023 Apr 26.

Abstract

Converter gas is a large scale waste product that is usually burned to carbon dioxide and contributes to the world emission of greenhouse gases. Herein we demonstrate that instead of burning the converter gas can be used as a reducing agent in organic reactions to produce valuable pharmaceuticals and agrochemicals. In particular, amide-based selected drug molecules have been synthesized by a reaction of aromatic nitro compounds and carboxylic acids in the presence of converter gas. In addition, we showed that this gas can also be conveniently utilized to carryout classical reductive amination reaction.