Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency

Tae Yong Park; Moon Young Choi; Dong Soo Kim; Jeong Kyun Yeo; Mahadevan Rajasekaran; Min Gu Park

doi:10.5534/wjmh.220274

Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency

World J Mens Health. 2024 Jan;42(1):178-187. doi: 10.5534/wjmh.220274. Epub 2023 Apr 19.

Authors

Tae Yong Park^#^{1

2}, Moon Young Choi^#³, Dong Soo Kim⁴, Jeong Kyun Yeo⁵, Mahadevan Rajasekaran⁶, Min Gu Park⁷

Affiliations

¹ Department of Medicine, Graduate School, Korea University, Seoul, Korea.
² Department of Urology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea.
³ Sports Medical Center and Sports Medicine Research Institute, Inje University Seoul Paik Hospital, Seoul, Korea.
⁴ Department of Urology, Kyung Hee University Medical Center, School of Medicine, Kyung Hee University, Seoul, Korea.
⁵ Department of Urology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
⁶ Department of Medicine, VA San Diego Health Care System, University of California, San Diego, CA, USA.
⁷ Department of Urology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. uromgpark@gmail.com.

^# Contributed equally.

Abstract

Purpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone levels and hypogonadal symptoms.

Materials and methods: Seventy patients with TD were divided into control (group I, n=23) and experimental (group II, n=47) groups. Patients in the experimental group were administered intramuscular testosterone enanthate (250 mg) for six months. The aging males symptom scale (AMS) score, international prostate symptom score (IPSS), body mass index, waist circumference, and serum laboratory values were measured at baseline and at the end of the study. Bioelectrical impedance analysis was used to assess the patients' body composition. Seven types of basic exercise tests were used to evaluate the patients' physical fitness.

Results: After six months, there were no significant differences in group I, while group II had significantly improved IPSS and AMS scores; increased hemoglobin, hematocrit, prostate-specific antigen, and testosterone levels and skeletal muscle mass; and waist circumference, and body fat mass. All elements of the physical fitness test were significantly improved in group II, with the exceptions of flexibility and endurance. Decreased waist circumference was correlated with changes in testosterone levels in group II, and the IPSS, cardiorespiratory fitness, and agility were correlated with improved hypogonadal symptoms.

Conclusions: TT improved the hypogonadal and lower urinary tract symptoms in patients with TD and improved body composition, physical fitness, and metabolic syndrome parameters. Increased testosterone and improved hypogonadal symptoms were correlated with a decrease in waist circumference and an improvement in cardiorespiratory fitness and agility. As such, when implementing TT, we should consider whether these areas may be improved, as this can help to predict the effect.

Keywords: Body composition; Hormone replacement therapy; Hypgonadism; Lower urinary tract symptoms; Physical fitness; Testosterone.

Abstract

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