The end of the beginning in understanding SLC22 polyspecificity

Marleen Julia Meyer-Tönnies; Mladen Vassilev Tzvetkov

doi:10.1016/j.tips.2023.04.001

The end of the beginning in understanding SLC22 polyspecificity

Trends Pharmacol Sci. 2023 Jul;44(7):397-399. doi: 10.1016/j.tips.2023.04.001. Epub 2023 Apr 27.

Authors

Marleen Julia Meyer-Tönnies¹, Mladen Vassilev Tzvetkov²

Affiliations

¹ Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald, Germany.
² Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald, Germany. Electronic address: mladen.tzvetkov@uni-greifswald.de.

PMID: 37117104
DOI: 10.1016/j.tips.2023.04.001

Abstract

SLC22 transporters involved in drug elimination and organ distribution are polyspecific. Now, the first cryo-EM structure of SLC22A3 (OCT3) is available from the Sitte and Korkhov groups. It paves the way for better understanding OCT3 function and for revealing the exact mechanisms conferring polyspecificity of the whole SLC22 family.

Keywords: SLC22 transporter; cryo-EM structure; genetic variants; organic cation transporter; polyspecificity; structure–function.

MeSH terms

Humans
Organic Cation Transport Proteins*

Substances

Organic Cation Transport Proteins