Transient perinatal metabolic shifts determine neuronal survival and functional circuit formation

Franck Oury; Alessandra Pierani

doi:10.1016/j.cell.2023.03.027

Transient perinatal metabolic shifts determine neuronal survival and functional circuit formation

Cell. 2023 Apr 27;186(9):1819-1821. doi: 10.1016/j.cell.2023.03.027.

Authors

Franck Oury¹, Alessandra Pierani²

Affiliations

¹ Université Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France.
² Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, F-75015 Paris, France; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, F-75014 Paris, France; GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, F-75014 Paris, France. Electronic address: alessandra.pierani@inserm.fr.

PMID: 37116467
DOI: 10.1016/j.cell.2023.03.027

Abstract

Metabolic changes are essential for neurodevelopmental processes. However, little is known about how and when neuronal metabolic remodeling occurs to promote functional circuits. In this issue of Cell, Knaus et al. demonstrate that a temporary perinatal shift in metabolites and lipids is crucial for cortical neurons' survival and wiring.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Survival
Neuronal Plasticity / physiology
Neurons* / physiology