Association of weight range with telomere length: A retrospective cohort study

Xinyu Wang; Jingli Wen; Qiang Qu; Shujun Gu; Lixi Zhang; Yu Li; Xu Qi

doi:10.3389/fendo.2023.1106283

Association of weight range with telomere length: A retrospective cohort study

Front Endocrinol (Lausanne). 2023 Apr 11:14:1106283. doi: 10.3389/fendo.2023.1106283. eCollection 2023.

Authors

Xinyu Wang¹, Jingli Wen¹, Qiang Qu², Shujun Gu¹, Lixi Zhang¹, Yu Li³, Xu Qi^{1

4}

Affiliations

¹ Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
³ School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
⁴ Department of Respiratory and Critical Care Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, China.

Abstract

Objective: Previous research has shown a significant association between weight and telomere length, but did not take into consideration weight range. The study was to investigate the association of weight range with telomere length.

Methods: Data of 2918 eligible participants aged 25-84 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 cycle were analyzed. Information about demographic variables, lifestyle factors, anthropometric variables, and medical comorbidities were included. Univariate and multivariate linear regression model with adjustments for potential confounders were employed to determine the association between weight range and telomere length. A non-parametrically restricted cubic spline model was used to illustrate the possible non-linear relationship.

Results: In univariate linear regression, BMI_max, BMI range, and weight range all revealed significant negative associations with telomere length. However, annual rate of BMI/weight range showed a significant positive associations with telomere length. There was no significant association between telomere length and BMI_min. After adjusting for potential confounders, the inverse associations persisted in BMI_max (β=-0.003, P<0.001), BMI range (β=-0.002, P=0.003), and weight range (β=-0.001, P=0.001). Furthermore, annual rate of BMI range (β=-0.026, P=0.009) and weight range (β=-0.010, P=0.007) presented negative associations with telomere length, after adjusting for covariates in Model 2-4. The association between BMI_min (β =-0.002, P=0.237) and telomere length still could not reach statistical significance in multivariate linear regression model. The results of restricted cubic spline analysis showed that BMI_max (P for nonlinear =0.026), BMI range (P for nonlinear =0.022), weight range (P for nonlinear =0.035), annual rate of BMI range (P for nonlinear =0.030), and annual rate of weight range (P for nonlinear =0.027) all had nonlinear inverse associations with telomere length.

Conclusions: The study suggests that weight range is inversely associated with telomere length in U.S. adults. Larger weight fluctuation may accelerate telomere shortening and aging.

Keywords: NHANES; aging; metabolic dysregulation; obesity; telomere length; weight range.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aging*
Humans
Nutrition Surveys
Retrospective Studies
Telomere / genetics
Telomere Shortening*

Grants and funding

This work was sponsored by the General Project of Jiangsu Provincial Health Commission (No. H2019029), the Jiangsu Province Six One Project (No. LGY2018054), the “Six talent peaks” high-level talents level B (No. WSN-015), and the 333 High-level personnel Training Program.