Immunological imprinting: Understanding COVID-19

Marios Koutsakos; Ali H Ellebedy

doi:10.1016/j.immuni.2023.04.012

Immunological imprinting: Understanding COVID-19

Immunity. 2023 May 9;56(5):909-913. doi: 10.1016/j.immuni.2023.04.012. Epub 2023 Apr 19.

Authors

Marios Koutsakos¹, Ali H Ellebedy²

Affiliations

¹ Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
² Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: ellebedy@wustl.edu.

Abstract

Immunological imprinting generically refers to the effects prior exposures have on subsequent immune responses to, and eventually protection against, antigenically related viruses. Here, Koutsakos and Ellebedy explain different concepts and terms around imprinting and the fundamental immunological principles behind it. They also discuss the potential role imprinting may have in the context of COVID-19 vaccines.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Vaccines*
COVID-19*
Humans

Substances

COVID-19 Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding